Peroxynitrite-induced a-actinin nitration and contractile alterations in isolated human myocardial cells
نویسندگان
چکیده
Division of Clinical Physiology, Institute of Cardiology, UD MHSC, P.O. Box 1, H-4004 Debrecen, Hungary Department of Medical Chemistry, UD MHSC, P.O. Box 1, H-4004 Debrecen, Hungary USZ Department of Pharmacology and Pharmacotherapy, P.O. Box 427, H-6701 Szeged, Hungary Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands
منابع مشابه
Peroxynitrite-induced alpha-actinin nitration and contractile alterations in isolated human myocardial cells.
OBJECTIVE Peroxynitrite-mediated myocardial protein nitration has been associated with a depressed cardiac pump function. In the present study, an attempt was made to elucidate the molecular background of peroxynitrite-evoked alterations in the human myocardium. METHODS Isometric force generation was measured in permeabilized human ventricular myocytes and biochemical methods were employed to...
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